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SECTION I: Movement Disorders (Joel Perlmutter, Washington University) 1. History of Parkinsonism Michael Silver, MD and Stewart A. Factor, DO 2. Parkinson Disease: Pathophysiology, Clinical Manifestations and Course including Diagnosis and Differential Diagnosis Michael J. Soileau, MD and Kelvin L. Chou, MD 3. Parkinson Disease: Treatment, Current Clinical Trials Thien Thien Lim, MD and Hubert H. Fernandez, MD 4. Parkinson Syndromes: Multiple System Atrophy Melvin W. Kong, MD and Ejaz A. Shamim MD, MS 5. Parkinson Syndromes: Progressive Supranuclear Palsy Vikas Kotagal, MD, MS and Praveen Dayalu, MD 6. Parkinson Syndromes: Corticobasal Degeneration Sami Barmada, MD, PhD 7. Huntington Disease: Etiology, Genetics, and Clinical Manifestations Roger L. Albin, MD and Henry L. Paulson, MD, PhD 8. Huntington Disease: Treatment, Current Clinical Trials Charles S. Venuto, PharmD and Karl Kieburtz, MD, MPH 9. Essential Tremors Arif Dalvi, MD, MBA, Kelly E. Lyons, PhD, and Rajesh Pahwa, MD 10. Dystonia: History and Classification H. A. Jinnah, MD, Cecilia N. Prudente, MD, Samuel J. Rose, MD and Ellen J. Hess, MD 11. Dystonia: Pathophysiology, Clinical Manifestations and Course Including Diagnosis, and Differential Diagnosis, Treatment, Current Clinical Trials Jeri Yvonne Williams, MD and David G. Standaert, MD, PhD 12. Paroxysmal Dyskinesias Olga Waln, MD and Joseph Jankovic, MD. 13. The Expanded Polyglutamine Tract Spinocerebellar Ataxias Elsdon Storey, MD 14. Ataxias: Autosomal Recessive and other Ataxias Vikram G. Shakkottai, MD, PhD SECTION II: Dementias (David Knopman, Mayo Clinic) 15. Alzheimer's Disease: Pathology and Pathogenesis Bradley T Hyman, MD, Beatriz G Perez-Nievas, MD, Isabel Barroeta-Espar, MD, Alberto Serrano-Pozo, MD, Matthew Frosch, MD, and Teresa Gomez-Isla, MD 16. Alzheimer's Disease: Clinical Manifestations and Diagnostic/Differential Diagnosis Michael S. Rafii, MD, PhD 17. Alzheimer's Disease: Management and Treatment Gregory A. Jicha, MD, PhD and Frederick A. Schmitt, PhD 18. Frontotemporal Degenerations Jonathan Graff-Radford, MD, and Keith A. Josephs, MD, MST, MSc 19. Diagnosis and Therapy for Lewy Body Dementia Bela R. Turk, MD and Ali Fatemi, MD 20. Pathogenesis of Lewy Body Dementia Jagan A. Pillai, MD, PhD and James B. Leverenz, MD 21. Cerebrovascular Dementia Rahul Karamchandani, MD and Nancy R. Barbas, MD, MSW SECTION III: Motorneuron Diseases (Merit Cudkowicz, Massachusetts General Hospital, Harvard University) 22. Types of MNDS Nimish Thakore, MD and Erik P. Pioro, MD, PhD 23. Clinical Presentations, Diagnostic Criteria, Lab Testing Nimish Thakore, MD and Erik P. Pioro, MD, PhD 24. Symptomatic Care Matthew Gladman, MD and Lorne Zinman, MD, MSc 25. ALS: Epidemiology Éilis J. O'Reilly, ScD 26. ALS: Pathogenesis Laura Ferraiuolo, MD and Stephen J. Kolb, MD 27. ALS: Insights from Genetics Matthew B. Harms, MD and Timothy M. Miller, MD, PhD 28. ALS: In Vitro and In Vivo Disease Models Brian J. Wainger, MD, PhD 29. ALS Pathology Brent T. Harris, MD, PhD, Galam A. Khan, MD, and Saed Sadeghi, MD 30. ALS: Clinical Trials Past Reflections Informing New Directions Katharine A. Nicholson, MD and James D. Berry, MD 31. Upper Motor Neuron Disorders: Hereditary Spastic Paraplegia and Primary Lateral Sclerosis John K. Fink, MD 32. UMN Disorders (HSP and PLS): Pathogenesis, Insights from Genetics, In Vitro and In Vivo Disease Models, Pathology and Clinical Trials Sabrina Paganoni, MD, PhD and Nazem Atassi, MD, MMSc 33. SMA: Pathogenesis Umrao R. Monani, PhD and Darryl C. De Vivo, MD 34. SMA: Insights from Genetics Arthur H.M. Burghes, MD and Vicki L. McGovern, MD 35. SMA: In Vitro and In Vivo Models of Spinal Muscular Atrophy W. David Arnold, MD and Arthur H.M. Burghes, MD SECTION IV: Paroxysmal Disorders (Solomon Moshe, Albert Einstein College of Medicine) 36. Biological Basis of Primary Generalized Epilepsies-Genetics Carla Marini, MD and Renzo Guerrini, MD 37. Biological Basis of Primary Generalized Epilepsies - Pathophysiology Mark W. Youngblood, MD and Hal Blumenfeld, MD 38. Temporal Lobe Epilepsy Edward H. Bertram, MD 39. Focal Cortical Dysplasias Ali Mahta, MD and Peter B. Crino, MD, PhD 40. Biological Bases of Symptomatic Generalized Epilepsies in Children Dragos A. Nita, MD, Miguel A. Cortez, MD, Jose Luis Perez Velazquez, MD, and O. Carter Snead 3rd, MD 41. Epilepsies that Occur Predominantly in Girls Lynette G Sadleir, MD, Jozef Gecz, MD, and Ingrid E Scheffer, MD 42. Epidemiology of Epilepsy: Incidence, Prevalence, and Risk Factors Dale C Hesdorffer, PhD, MPH 43. Clinical Presentation, Diagnosis, and Course- Epilepsy Syndromes with Focal Seizures Alex Boro, MD and Jerome Engel, Jr., MD 44. Medical Management of Epilepsy Jules C. Beal, MD and Emilio Perucca, MD 45. Neuroimaging in Epilepsy William A. Gomes, MD, PhD 47. Alternative Therapies for Epilepsy: Dietary Treatments Carl E. Stafstrom, MD, PhD 48. Migraine and Other Headache Disorders Robert W. Charlson, MD and Matthew S. Robbins, MD 49. Neurobiology of Migraine Victor Rosenfeld, MD and John Stern, MD SECTION V: Pediatric Neurology and Developmental Disorders (Tanjala Gipson and Deepa Menon, Kennedy Krieger Institute and Johns Hopkins University) 50. Autism and Intellectual Disabilities: Overview of Autism and Intellectual Disabilities Tanjala T. Gipson, MD and Michael V. Johnston, MD 51. Tuberous Sclerosis Complex: Pediatric Aspects Tanjala T. Gipson, MD, Andrea Poretti, MD, Rebecca McClellan, MGC, CGC, and Michael V. Johnston, MD 52. Neurofibromatosis Type 1 David S. Wolf, MD, PhD 53. Neurobiology of Autism and Intellectual Disability: Fragile X Syndrome Dejan B. Budimirovic, MD and Megha Subramanian, BA 54. Autism and Intellectual Disabilities: PTEN Gene mutation Deepa U. Menon, MBBS, MD 55. Rett Syndrome C.L. Smith-Hicks, MD and SakkuBai Naidu, MD 56. Angelman Syndrome Kristin W. Barañano, MD, PhD 57. Down Syndrome George T. Capone, MD 58. Coffin-Lowry Syndrome Michael V. Johnston, MD 59. Congenital Hypothyroidism Mary Lee Gregory, MD, PhD 60. Pediatric Neurotransmitter Disorders Phillip L. Pearl, MD and William P. Welch, MD 61. Attention Deficit-Hyperactivity Disorder Mihee J. Bay, MD and Bruce K. Shapiro, MD 62. Diseases of Mitochondrial Energy Metabolism Jacqueline Weissman, MD, MS and Lisa Emrick, MD 63. Genetic Metabolic Disorders: MethylmalonicAciduria Siddharth Srivastava, MD and Jeffrey Chinsky, MD PhD 64. The Urea Cycle Disorders Andrea L. Gropman, MD, Belen Pappa, MD, and Nicholas Ah Mew, MD 65. Phenylketonuria Hilary Vernon, MD, PhD 66. Cerebral Creatine Deficiency Disorders Peter W. Schutz, MD and Sylvia Stockler, MD 67. Congenial Disorders of Glycosylation Marc C. Patterson, MD, FRACP 68. Glutaric Aciduria Type I Hilary Vernon, MD, PhD 69. Lysosomal Storage Disroders Gustavo H.B. Maegawa, MD, PhD, FACMG 70. Peroxisomal Disorders Gerald V. Raymond, MD, Mohamed Y. Jefri, MD, Kristin W. Baranano, MD, and Ali Fatemi, MD 71. Leukodystrophies Ulrike Schrifl, MD, SakkuBai Naidu, MD, and Ali Fatemi, MD 72. Cerebral Palsy Joan M. Jasien, MD, Bruce K. Shapiro, MD and Alexander H. Hoon, Jr., MD 73. Neonatal Brain Injuries Katharina Goeral, MD, Ali Fatemi, MD, and Michael V. Johnston, MD 74. The Neurobiology of Encephalopathy of Prematurity Gwendolyn J. Gerner, MD and Vera Joanna Burton, MD 75. Epilepsy Syndromes in Childhood Verena Staedtke, MD and Eric H. Kossoff, MD 76. Migraine and Headaches in Children Jessica Klein, MD and Christopher Oakley, MD 77. Congenital Hydrocephalus Vera Joanna Burton, MD and Edward Ahn, MD 78. Spina Bifida and Related Conditions Stephen L. Kinsman, MD 79. Smith-Lemli-Opitz Syndrome Ryan W. Lee, MD 80. Sickle Cell Anemia Eboni I. Lance, MD SECTION VI: Neuroimmunological Diseases (Carlos Pardo-Villamizar, Johns Hopkins University) 81. The Epidemiology of Multiple Sclerosis: An Historical Perspective Kassandra L. Munger, ScD 82. Multiple Sclerosis: Pathology Bogdan Florin Gh. Popescu, MD, Yong Guo, MD, and Claudia Francesca Lucchinetti, MD 83. Multiple Sclerosis: MRI and Other Imaging Approaches in MS Martina Absinta, MD and Daniel S. Reich, MD, PhD 84. Multiple Sclerosis: White Matter vs Grey Matter Involvment (The Cause of Disability in MS) Massimo Filippi, MD, and Maria A. Rocca, MD. 85. Multiple Sclerosis: Monitoring disease activity and progression Pavan Bhargava, MD and Shiv Saidha, MBBCh, MD, MRCPI 86. Symptomatic Treatment of Multiple Sclerosis Kathleen Costello, RN, BSN, MS 87. Exercise and Multiple Sclerosis Jeffrey R Hebert, PT, PhD 88. Multiple Sclerosis: Disease Modifying Therapies Pavan Bhargava, MD and Peter A. Calabresi, MD 89. Neuromyelitis Optica Teri L. Schreiner, MD, MPH and Jeffrey L. Bennett, MD, PhD 90. Acute Disseminated Encephalomyelitis Benjamin M. Greenberg, MD, MHS and Allen Desena, MD 93. Paraneoplastic Neurological Disorders John C. Probasco, MD 94. Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Encephalitis Elizabeth M. Wells, MD, MHS 95. Other Proven and Putative Autoimmune Disorders of the CNS: Anti-GAD Associated Neurological Disorders; Stiff-Person syndrome, Cerebellar Ataxia, Progressive Encephalopathy with Rigidity and Myoclonus (PERM), and Encephalitis. Scott D. Newsome, DO 96. Other Proven and Putative Autoimmune Disorders of the CNS: Hashimoto's Encephalopathy Eoin P. Flanagan, MBBCh and Richard J. Caselli, MD 97. Other Proven and Putative Autoimmune Disorders of the CNS: Neuro-Bechet's Syndrome Afshin Borhani Haghighi M.D and Bernadette Kalman, MD, PhD, DSc 98. Post-Streptococcal Movement Disorders Davide Martino, MD and Gavin Giovannoni, MD 99. Rasmussen Encephalitis Jan Bauer, MD and Christian G. Bien, MD 100. Autoimmune Encephalitis Andrew McKeon, MD 101. Other Proven and Putative Autoimmune Disorders of the PNS: Myasthenia gravis Doris G. Leung, MD 102. Vasculitis of the central nervous system Christian Pagnoux, MD and Richard H. Swartz, MD SECTION VII: Cerebrovascular Diseases (Harold Adams, University of Iowa) 103. Stroke Epidemiology and Impact: Mortality, Incidence, Prevalence, Stroke Subtypes, Sex, Race/Ethnicity, Geography U.S. and World Virginia J Howard, PhD 104. Acute Ischemic Stroke Harold P. Adams, Jr., MD 105. Neuroimaging of Acute Stroke Chelsea S. Kidwell, MD and Kambiz Nael, MD 106. Common Risk Factors and Medical Prevention Therapies George Khouri, MD, Shelly Ozark, MD, and Bruce Ovbiagele, MD, MSc, MAS 107. Surgical and Radiologic Intervention for Prevention of Ischemic Stroke Andrew Ringer, MD 108. Unusual Causes of Stroke Enrique C. Leira, MD, MS 109. Pediatric Stroke Melissa Chung, MD and Warren Lo, MD 110. Vascular Biology of Cerebral Ischemia Jason A. Ellis, MD and E. Sander Connolly, Jr., MD 111. Intracerebral Hemorrhage Craig Anderson, MD 112. Subarachnoid Hemorrhage David Hasan, MD 113. Genetics of Cerebral Ischemia including Genetic Syndromes Andrea Porretti, MD and Michael V. Johnston, MD 114. Molecular Targets of Cerebral Ischemia Ryan J. Felling, MD, PhD 115. Sturge-Weber Syndrome and related Cerebrovascular Malformation Syndromes. Angela Quain, MS and Anne M. Comi, MD SECTION VIII: Peripheral and Autonomic Nervous System Disorders and Pain (Nicholas Maragakis, Johns Hopkins University) 116. Neuropathies Associated with Infection or Toxic Exposure Doris Leung, MD 117. Mechanisms Contributing to the Development and Progression of Diabetic Polyneuropathy Lucy M. Hinder, PhD, Kelli A. Sullivan, PhD, Stacey A. Sakowski, PhD, and Eva L. Feldman, MD, PhD 118. Diabetic and PreDiabetic Neuropathy Lindsay Zilliox, MD and James W. Russell, MD, MS, FRCP 119. Anatomy, Localization, and Pattern Recognition of Peripheral Neuropathy Noah Kolb, MD and A. Gordon Smith, MD 120. Drug Discovery of Neuropathic Pain Brian J. Wainger, MD, PhD 121. Neuropathies, Autonomic Phillip A. Low, MD 122. Animal Models of Peripheral Neuropathy and Neuropathic Pain Katelyn Donaldson, MD and Ahmet Höke, MD, PhD 123. Diagnostic Tests and Clinical Scales for Peripheral Neuropathy John D. Markman, MD 124. Complex Regional Pain Syndrome Frank S. Pidcock, MD 125. Entrapment Neuropathies James W. Teener, MD 126. Demyelinating Neuropathies John A. Goodfellow, MD, Amy I. Davidson, MD, and Hugh J. Willison, MD 127. Immune Mediated Neuropathies John A. Goodfellow, MD, Amy I. Davidson, MD, and Hugh J. Willison, MD 128. Radiculopathy and Plexopathy Michael Wheaton, MD, Dustin Nowacek, MD, and Zachary London, MD SECTION IX: Neoplastic and Paraneoplastic Diseases (Lisa DeAngelis, Memorial Slaon-Kettering Cancer Center) 129. Infiltrative Astrocytomas: WHO grade II - Diffuse Astrocytoma; WHO grade III - Anaplastic Astrocytoma Aaron Mammoser, MD, MS 130. Glioblastomas Aaron Mammoser, MD, MS 131. Oligodendrogliomas Thomas J. Kaley, MD 132. Primary CNS Tumores: Ependymomas Brett J. Theeler, MD and Mark R. Gilbert, MD 133. Meningiomas Jennie Taylor, MD and Patrick Y. Wen, MD 134. Pineal Region Neoplasms Neil Haranhalli, MD and Jerome J. Graber, MD, MPH 135. Pituitary Tumors Toral R. Patel, MD and Viviane S. Tabar, MD 136. Primary Central Nervous System Lymphoma Lisa M. DeAngelis, MD 137. Familial CNS Tumor Syndromes: Neurofibromatosis Type 1 Ibrahim Hussain, BA and David H. Gutmann, MD, PhD 138. Familial CNS Tumor Syndromes: Neurofibromatosis Type-2 Jennie W. Taylor, MD and Scott R. Plotkin, MD, PhD 139. Familial CNS Tumor Syndromes: Tuberous Sclerosis Darcy A. Krueger, MD, PhD 140. Familial CNS Tumor Syndromes: Von Hippel-Lindau Disease Gurvinder Kaur, MD, Leonel Ampie, MD, Joseph Weiner, MD, and Aruna Ganju, MD 141. Pediatric Tumors: Pontine Glioma Kristin Schroeder, MD, MPH and Oren Becher, MD 142. Pediatric Tumors: Medulloblastoma Kevin C De Braganca, MD and Roger J. Packer, MD 143. Pediatric Tumors: Cerebellar Astrocytoma Vijay Ramaswamy, MD, FRCPC, Jason T. Huse, MD, PhD, and Yasmin Khakoo, MD 144. Brain Metastases Jasmin Jo, MD and David Schiff, MD 145. Overview: Other Proven and Putative Autoimmune Disorders of the CNS Myrna R. Rosenfeld, MD, PhD, Maarten J. Titulaer, MD, PhD, and Josep Dalmau, MD, PhD 146. Chemotherapy and Radiation Therapy Mary R. Welch, MD and Craig Nolan, MD SECTION X: Infectious Diseases of the Nervous System (Karen Roos, Indiana University) 147. Acute Bacterial Meningitis Pratibha Singhi, MD, PhD, Naveen Sankhyan, MD, PhD, and Sunit Singhi, MD, PhD 148. Cerebrospinal Fluid John E. Greenlee, MD 149. History of Human Immunodeficiency Virus Infection and the Nervous System Avindra Nath, MD 150. HIV-Associated Neurocognitive Disorders Joshua Alexander, DO, MPH, David J Croteau, MD, FRCPC, and Ronald J Ellis, MD, PhD 151. HIV Infection: Opportunistic Infections in HIV-Infected Individuals William Tyor, MD 152. Varicella Zoster Virus Infection of the Nervous System Don Gilden, MD, Randall J. Cohrs, PhD, Ravi Mahalingam, PhD, and Maria A. Nagel, MD 153. Brain Abcess Bela R. Turk, MD, Ali Fatemi, MD, and Michael V. Johnston, MD 154. Epidural Abscess and Sudural Empyema Tyler R West, DO and Kelly J Baldwin, MD 155. Spinal Epidural Abcess Minal A. Shah, MD and Rabih O. Darouiche, MD 156. Transverse Myelitis Ivana Vodopivec, MD, PhD and Tracey A. Cho, MD 157. CNS Tuberculosis Andrea T. Cruz, MD, MPH, and Jeffrey R. Starke, MD 158. Rabies Alan C. Jackson, MD 159. Disorders Caused by Botulinum Toxin and Tetanus Toxin Carl E. Stafstrom, MD, PhD 160. Rickettsial Diseases Lisa Sun, MD and Michael V. Johnston, MD 161. Ehrlichial Diseases Nicholas S. Havens, MD and William E. Roland, MD, FACP 162. Nervous System Lyme Disease John J. Halperin, MD 163. Congenital and Perinatal Viral Infections James F. Bale, Jr., MD 164. Neurologic Manifestations of HTLV-1 Abelardo Q-C Araujo, MD, MSc, PhD, FAAN 165. Fungal Infections of the Central Nervous System Pratibha Singhi,MD, Karthi Nallasamy, MD, and Sunit Singhi, MD 166. Malaria Kiran Thakur, MD 167. Babesiosis Kristyn E. Feldman, MD and Joshua Biddle, MD 168. Amebic Encephalitis Pratibha Singhi, MD and Arushi G. Saini, MD 169. Prions James A. Mastrianni, MD, PhD and Joshuae G. Gallardo, MD 170. Neurological Complications of Infective Endocarditis Jonah Grossman, MD, Tanzila Shams, MD, and Cathy Sila, MD 171. Post-Infectious Encephalitis Agusto A. Miravalle, MD 172. Central Nervous System Whipple Disease Arun Venkatesan, MD, PhD 173. Progressive Multifocal Leukoencephalopathy Arun Swaminathan, MBBS and Joseph R. Berger, MD SECTION XI: Sleep Disturbances (Mark Dyken, University of Iowa) 174. REM Sleep Behavior Disorder Shannon S. Sullivan, MD 175. Restless Leg Syndrome and Periodic Limb Movements in Sleep Jennifer Accardo, MD, MSCE 176. Insomnia Wilfred R. Pigeon, MD and Henry J. Orff, MD 177. Sleep Apnea Jennifer Accardo, MD, MSCE 178. Neurobiology of Circadian Rhythm Disorders Christopher R. Jones, MD, PhD SECTION XII: Substance Abuse and Toxicological Disorders (Barry Kosofsky, Weil-Cornell University Medical Centers) 179. Neurologic Manifestations of Organic Chemicals John L. O'Donoghue, VMD, PhD, DABT 180. Neurobiology of Drug Addiction and Clinical Aspects of Drug Abuse Leslie R. Whitaker, MD and Bruce T. Hope, MD 181. Neurological Effects of Marine Toxins Kazuma Nakagawa, MD 182. Fetal Alcohol Syndrome Carmen Lopez-Arvizu, MD, Carmel Bogle, MD, and Harolyn M.E. Belcher, MD, MHS 183. Fetal Exposure to Tobacco and Cannabis Edore C. Onigu-Otite, MD 184. Neurobiology of Child Maltreatment and Psychological Trauma Nikeea Copeland-Linder, PhD, MPH, Edore Onigu-Otite, MD, Jennifer Serico, PhD, Mariflor Jamora, MD, and Harolyn M.E. Belcher, MD, MHS 185. Neurobiology of Intrauterine Opiate and Cocaine Exposure Harolyn M.E. Belcher, MD, MHS and Samantha Hutchison, MD SECTION XIII: Neurologic Manifestations of Medical Disorders (John Probasco, Johns Hopkins University) 186. Electrolyte Disturbances Mark N. Rubin, MD and Alejandro A. Rabinstein, MD 187. Nutritional Deficiencies Deanna Saylor, MD, MHS and John C. Probasco, MD 188. Alcohol Abuse Killian A. Welch, MD 189. Thyroid Disease Makoto Ishii, MD, PhD 190. Parathyroid, Adrenal, Ovarian, Testicular and Pituitary Disease Gary M. Abrams, MD 191. Cardiac Disease Roger E. Kelley, MD 192. Neurobiology of Brain Injury after Cardiac Arrest Lucia Rivera-Lara, MD and Romergryko G. Geocadin, MD 193. Gastrointestinal Disease Brian P. Bosworth, MD, Brian R. Landzberg, MD, and Elisa McEachern, MD 194. Neurological Manifestations of Renal Disease Joshua S. Hundert, MD, Rashmi Verma, MD, Ritika Suri, MD, Anika T. Singh, MD, and Ajay Singh, MD 195. Systemic Lupus Erythematosis Richard B. Rosenbaum, MD 196. Neurologic Manifestations of Hematological Disease Elham Bayat, MD

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