The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child's risk. • Provides insights into diseases that could be prevented, along with the challenges facing research scientists in the world of vaccines • Gives new ideas about future vaccines and concepts • Introduces new vaccines and concepts • Gives ideas about challenges facing public and private industrial investors in the vaccine area • Discusses the problem of declining immunization rates and vaccine hesitancy
Part I: Understanding Vaccine Impact at Population and Individual Levels 1. The Impact of Vaccination on the Epidemiology of Infectious Diseases 2. How Vaccines Work Part II: How to Design, Assess and Produce Vaccines 3. Vaccine Design in the 21st Century 4. Vaccine Adjuvants 5. Vaccine Production: Main Steps and Considerations 6. How are Vaccines Assessed in Clinical Trials? 7. Immunological Correlates of Vaccine-Mediated Protection Part III: Vaccine Safety 8. How Vaccine Safety is Monitored 9. Vaccination and Autoimmune Diseases Part IV: New Vaccination Strategies 10. Maternal Immunization: Protecting Vulnerable Populations 11. New Challenges for Pertussis Vaccines Part V: Recently Introduced Vaccines 12. Pneumococcus, Pneumococcal Disease, and Prevention 13. Human Papillomavirus Vaccines 14. Rotavirus Vaccines Part VI: New Approaches for Needed Vaccines 15. Antiviral Vaccines: Challenges and Advances 16. New Approaches for Needed Vaccines: Bacteria 17. Vaccines Against Parasites Part VII: Major Global Vaccine Challenges 18. Tuberculosis Vaccines 19. Major Global Vaccine Challenges: Recent Progress in Malaria Vaccine Development 20. AIDS Vaccines 21. Influenza Vaccines and Vaccination Strategies Part VIII: Ethical Considerations 22. Ethical Considerations in Vaccine Trials in Resource-Limited Settings Part IX: Vaccine Economics 23. Economic Considerations for the Development of Global Vaccines: a Perspective From the Vaccine Industry 24. Introduction of Vaccines Into National Programs 25. Transitioning Immunization Into the Health Care System: Strengthening Routine Immunization in India Part X: Trust in Vaccines 26. Vaccine Acceptance 27. Trust and Confidence in Vaccines: Tales of Three Vaccines, Lessons for Others Part XI: Future Challenges 28. Vaccines for Emerging Viral Diseases 29. Cancer Immunotherapy by Checkpoint Blockade 30. Adoptive Cellular Therapy With Synthetic T Cells as an Instant Vaccine for Cancer and Immunity
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