Viruses: From Understanding to Investigation provides students with a map for lifetime learning by presenting the definition and unique characteristics of viruses, including major topics, such as the virus lifecycle, structure, taxonomy, evolution, history, host-virus interactions and methods to study viruses. In addition, the book assesses the connections between, and among, the aforementioned topics, providing an integrated approach and in-depth understanding of how viruses work. Employs a comparative strategy to emphasize unique structural and molecular characteristics that inform transmission, disease processes, vaccine strategies and host responses Presents a review of host cell and molecular biology and the immune system Features topical areas of research, including genomics in virus discovery, the virome, and beneficial interactions between viruses and their hosts Includes text boxes throughout with experimental approaches used by virologists Covers learning objectives for each chapter, methods and advances, question sets, quizzes and a glossary
1. A brief introduction to virology 2. The virus replication cycle 3. Virus structure 4. How we study viruses 5. Molecular and cell biology of the eukaryotic cell 6. Virus interactions with the host 7. Antiviral responses 8. An introduction to RNA viruses 9. Picornaviridae 10. Caliciviridae 11. Flaviviridae and Togaviridae 12. Order Nidovirales 13. Order Mononegavirales 14. Bunyaviridae 15. Arenaviridae 16. Orthomyxoviridae 17. Reoviridae 18. Introduction to DNA viruses 19. Poxviridae 20. Circoviridae 21. Parvoviridae 22. Papillomaviridae 23. Polyomaviridae 24. Adenoviridae 25. Herpesviridae 26. Viruses that use reverse transcription 27. The human hepatitis viruses 28. Evolution and genetics of viruses 29. Immune responses to viruses 30. Vaccines: Principles and approaches 31. Antiviral drugs and treatment strategies 32. Viral vectors and gene thereapy Appendix 1. The viruses we know -- lists, tables of taxonomy Appendix 2. Biochemical methods to study viruses -- analyzing proteins and nucleic acids Appendix 3. Tables describing morbidity and mortality (WHO) Appendix 4. Glossary
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