Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions.
This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases.
1. An Introduction: A Clinical Neuroscientist and Disorders of the Brain Section I: Developmental Disorders2. Introduction3. Developmental Disabilities and Metabolic Disorders4. Attention-Deficit/Hyperactivity Disorder5. Down Syndrome: A Model for Chromosome Abnormalities6. Autism Spectrum Disorder7. Rett Syndrome: From the Involved Genes to Treatment8. Fragile X-associated DisordersSection II: Diseases of the Peripheral Nervous System9. Introduction10. Myasthenia Gravis 11. Muscular Dystrophy12. Peripheral Neuropathies and Guillain-Barré Syndrome13. Diabetes and Its ConsequencesSection III: Diseases of the Central Nervous System and Neurodegeneration14. Introduction15. Spinal Cord Injury16. Traumatic Brain Injury17. Epilepsy18. ALS and Related Motor Neuron Disorders (Including Spastic Paraplegia)19. Parkinsonian Syndromes20. Huntington Disease21. Alzheimer Disease and Other Dementias22. Cerebrovascular Disease23. Prion DiseaseSection IV: Infectious and Immune-mediated Diseases Affecting the Nervous System24. Introduction25. Inflammation in Neurological Disease 26. Inflammation in Psychiatric Disease27. Infectious Diseases of the Nervous System28. AIDS29. Autoimmune Neurological Disorders: Idiopathic and Paraneoplastic30. Multiple SclerosisSection V: Diseases of Higher Function31. Introduction32. Disorders of Higher Cortical Function 33. Disorders of Frontal Lobe Function 34. Stress35. Addictions 36. Sleep Disorders, Narcolepsy, and Restless Leg Syndrome37. Anxiety Disorders and Post-traumatic Stress Disorder38. Obsessive Compulsive Disorder39. The Neurobiology of Schizophrenia 40. Bipolar Disorders41. Pain42. Headache and Migraine43. Depression and SuicideSection VI: Diseases of the Nervous System and Society44. Introduction45. Ethical Issues that Emerge from Research (Basic)46. Burden of Neurological Disease47. Stress, Race, and Health Disparities
